경구용 비스포스포네이트 관련 악골괴사의 진단 및 치료
Diagnosis and Treatment of Oral Administered Bisphosphonate-Related Osteonecrosis of the Jaw
임경섭, 마득현, 김수관, 문성용,
소속 상세정보
임경섭 ( Lim Kyung-Seop ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
마득현 ( Mah Deuk-Hyun ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
김수관 ( Kim Su-Gwan ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
문성용 ( Moon Seong-Yong ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
KMID : 1034220110030010004
Abstract
Objectives: Bisphosphonates(BP) have been widely used for treatment of osteoporosis. Even though the efficacy of bisphosphonate, their administration may cause Bisphosphonate-related osteonecrosis of the jaw(BRONJ). The accurate incidence, pathogenesis and risk factor of BRONJ have not been clear and appropriate guidelines for prevention and treatment has not established. The objective of this clinical study is to provide accurate scientific information and to improve of clinicians’ approach about BRONJ.
Methods: We evaluated 39 patients with BRONJ taking oral BP because of osteoporosis visited Chosun University Dental Hospital from January 2008 to December 2010. All of them were female average age was 72.5. The mean duration of taking BP is 2.5 years accompanied by various systemic diseases. Occuring areas are 22 in the lower jaw, and 8 in the maxillary bone, primarily in the mandible were predominantly caused by trauma such as tooth extraction.
Results: 2 cases of Stage 1, Stage 2 of the 27 cases, Stage 3 was classified 1 case. The result of treatment according to the guidelines was improvement of symptoms in 22 cases, but 8 cases was not, so conservative treatment and surgical procedures were performed repeatedly.
Conclusions: It is need to explain to the patients about possiblity of BRONJ after dental surgery. We must evaluate the potential states and another dangerous factor of osteonecrosis.
키워드
Bisphosphonate; Osteonecrosis of the jaw; BRONJ
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